+91 4933 271416
principal@alshifacollegeofpharmacy.ac.in
Apply Online Edu Grievance Student Registration
Alumni | Cloud Login | Placement| Career
  • Pharmaceutical Chemistry
  • FACULTY PROFILE
  • Research Facility
  • Patents & Publications
  • Photo Gallery

The Department of Pharmaceutical Chemistry is primarily involved in providing a strong foundation in fundamentals of different areas of chemistry viz. Organic chemistry, Inorganic chemistry, Biochemistry, Medicinal chemistry and Natural product chemistry.

The department consists of 11 permanent teaching faculties with a strong desire for academic excellence, including 3 Professors, 4 Associate Professors and 4 Assistant Professor, of which 3 holds PhD Degree. To support teaching faculties there are seven laboratory assistants. The faculties of the department are engaged in various research through international collaborations taking up the emerging challenges in health care.

The department has identified core areas of research mainly in medicinal chemistry in the fields of cancer, diabetes, inflammation and chemotherapy of microbial diseases. The prime motto of our research is to identify a lead molecule either of synthetic or natural origin and to optimize the lead to achieve desirable pharmacodynamic and pharmacokinetic properties. The methods to identify the lead applied in our department includes design, synthesis, SAR, characterization and screening of novel organic molecules using traditional as well as cutting edge technologies like high throughput screening and molecular modeling. Lead optimization is performed using computational methods.

The department is continuously updated every year. Updation includes the establishment of an enzyme assay and screening facility, the upgrade of computers in the CADD laboratory, and the upgrade of software in the “Centre for Experimental Drug Design and Development” lab. We also established the provisions to conduct experiments in an inert atmosphere and purchased instruments like a microcentrifuge, vortex mixture, melting point apparatus, deep freezer, and enzyme assay kit.

The department has access to UV-Visible, Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR), Mono-wave synthesizer, Rotary Flash evaporators, Micro plate Photometer, Microplate Washer, Micro plate incubation shaker, Fume hoods, Digital melting point apparatus, Vortex mixer, Rota mantles, digital hot tops and relevant instruments to give firsthand experience to the students. the results of these researches have been published in international scientific journals with good impact factors.

Most of the faculties and students presents their research works in various seminars and conferences and secure prizes. The department is actively mentoring the students for participating in various Innovation programmes across the countries and three projects have been selected for the district-level competition in the Young Innovation Programme organized by Govt. of Kerala.

Centre for Experimental Drug Design and Development

Our department has received a grant of Rs 11.33 Lakhs for the proposal entitled “Establishing Centre for Experimental Drug Design and Development” from All India Council for Technical Education (AICTE) under the Modernization and Removal of Obsolescence (MODROBS) scheme. The scheme aims to modernize and remove obsolescence in the Laboratories to enhance the functional efficiency of technical institutions for Teaching, Training, and Research . The lab is fully equipped with an array of instrumentation necessary to support work in areas such as chemical synthesis, drug discovery, and medicinal chemistry. We are committed to giving our chemistry students hands-on experience using state-of-the-art equipment in the early stages of study. Facilities available in the lab are

     
  • Monowave assisted reaction station
  • Rotavapors
  • Multiskan™ FC Microplate Photometer
  • Wellwash™ Microplate Washer
  • Fume Hood
  • Vacuum pumps
  • High Vacuum Pumps
  • Magnetic stirrers
  • Analytical and other scales
  • Dual wavelengths UV cabinets
  • Rotamantles
  • Heat Gun
  • Infrared thermometer
  • FT-IR ATR Bruker
  • Vacuum filtration assembly
  • Ice flaker
  • Digital melting point
  • Argon assisted organic synthesis.

Centre for Molecular Simulations and Drug Design

Centre for Molecular Simulations and Drug Design, under department of pharmaceutical chemistry was founded in November 2019. Over the last few years, computer aided drug design (CADD) has become a powerful technique because of its utility in various phases of drug discovery and development through various advanced features. This facility provides an ideal research environment for the complete spectrum of computer-assisted drug discovery for undergraduates, post graduates and research scholars. The students can understand how the drug discovery process works from the identification of molecular targets to the design of therapeutic candidates. The overall goal is to develop and apply innovative computational methodologies for drug design and discovery to address problems at the interface between chemistry, biology and medicine. Research activities of this laboratory focus on modelling protein-ligand interactions, structure-based drug design, molecular dynamics, Pharmacophore modelling, ADME prediction, homology modelling and QSAR. Among these, structure based drug design is our focus due to rapid growth in structural data (available in RCSB & Nucleic acid Data Bank). This structural data can be used in molecular modeling to design lead molecules based on the structural features of the active site to design several classes of bioactive compounds targeted to specific diseases. We are also interested to offer training programmes and research assistance to the students in areas like virtual screening based on the integration of docking, molecular dynamics, and free energy-based scoring functions. Our team has strong experience in this field and we are also in tight cooperation with leading groups from academia around the globe and published several research articles in reputed international peer reviewed journals. The department is equipped with five computer with high end configuration and various commercial as well as open source softwares to train the process of drug design

Book Chapters

  • Chandy steffy mary. "advanced drug discovery technique for identification of natural resourcesbas potential therapeutic agents." Natural medicine, edited by Raja chakraborty , saikat sen , Bentham , 2023, vol.2.99-119.
  • Rasheed arun . "A review on natural antioxidants." Traditional and complementary medicine, edited by cengiz mordeniz , intechopen , 2019, vol 5.
  • Rasheed arun. "Amino acid prodrug of nonsteroidal antinflammatory drug." abebooks , Lambert , 2017,ISBN 10: 6202060174.
  • Rasheed arun. "Prodrug of some antinflammatory drug -case studies." abebooks , Lambert , 2018,ISBN 10 : 6139915066.

Patents

  • Patent Title: STABILITY INDICATING METHOD DEVELOPMENT AND ITS VALIDATION FOR RIBAVIRIN BY RP-HPLC
    Patent Application Number : 202141056825A
    Date of filling : 07/12/2021
    Patent Number :
  • Patent Title: METHOD FOR THE DETERMINATION OF RELATIVE SUBSTANCES IN SULISOBENZONE BY USING RP HPLC
    Patent Application Number : 202241005918A
    Date of filling : 03/02/2022
    Patent Number :
  • Patent Title:NOVEL THERAPEUTIC METFORMIN BIOCONJUGATES SHOWING ENHANCED ANTI-DIABETIC ACTIVITY AND PHARMACOKINETIC PROPERTIES
    Patent Application Number : 202241059024 A
    Date of filling : 16/10/2022
    Patent Number :
  • Patent Title:NEUROPROTECTIVE EFFECT OF TAURINE HYBRIDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
    Patent Application Number : 202241059343 A
    Date of filling : 17/10/2022
    Patent Number :
  • Patent Title:GLYCINE-DEXIBUPROFEN PRODRUG FOR NEUROPROTECTIVE EFFECTS.
    Patent Application Number : 202441057502 A
    Date of filling : 29/07/2024
    Patent Number :
  • Patent Title:PHENYL ALANINE-DEXIBUPROFEN PRODRUG FOR TREATMENT OF ALZHEIMER’S DISEASE.
    Patent Application Number : 202441057129 A
    Date of filling : 29/07/2024
    Patent Number :

Publications

  • Goel T, Bansode D, Abdu RA, Dev S. Molecular Docking, Microwave-Assisted Synthesis, Characterization and Pharmacological Evaluation of 2,4,5-trisubstituted Imidazole’s. CMIC. 2023 Apr;10(1):43-52.
  • Naman Jain, Raihan Abdu , Omkar Tambekar , Mayuri Bedse, Tanvi Goel , Sanal Dev, Investigation of chalcone cyclized pyrazole derivatives as an anti-inflammatory agent: In-vivo and in-silico molecular docking approach. INDIAN J. CHEM.2023 may Vol. 6, pp. 465-471
  • eedikayil AT, Lee J, Abdelgawad MA, Ghoneim MM, Shaker ME, Selim S, et al. Inhibitions of monoamine oxidases by ferulic acid hydrazide derivatives: synthesis, biochemistry, and computational evaluation. Appl Biol Chem. 2023 Oct 5;66(1)
  • R S, Varghese N, Jacob J, B N, Rasheed SP, K P N, et al. A Phytochemical and Pharmacological Review of Sphagneticola trilobata (L.) Pruski. Int J Pharm Sci Rev Res. 2023 Mar 15;79(1):
  • Ananda M, Ghosh A, Mohandas H, Karmakar R, Nagesh B, S. Jubie S, et al. SYNTHESIS, molecular docking, in-silico admet screening, structural safety evaluation of abacavir sulfate and its novel modified substance. Rjc. 2023;16(03):1137-48.
  • Afanamol MS, Dinesh AD, Ali KS, Vengamthodi A, Rasheed A. Drug repurposing by in silico prediction of cyclizine derivatives as antihyperlipemic agents. In Silico Pharmacol. 2023 Oct 25;11(1)
  • K T N, Rasheed SP, KP N, R S, K MJ. Miracles of Herbal Phytomedicines as Potent Anti-Inflammatory Agents. Int J Pharm Sci Rev Res. 2023 Mar 15;79(1):
  • Rasheed SP, Shivashankar M. In-process Profiling of Herbomineral Formulation from Marine Origin. Jordan j pharm sci. 2023 Mar 25;16(1):30-45.
  • Azeez RFA, Zara S, Ricci A, Dev S, Vengamthodi A, Kavully FS, et al. Integrating N-alkyl amide in the chalcone framework: synthesis and evaluation of its anti-proliferative potential against AGS cancer cell line. Res Chem Intermed. 2023 Jan;49(1):203-20.
  • Jemi Jacob, Neethu Varghese , Nija B , Shebina P Rasheed , Aishwarya P and Muhammed Jamshad recent small molecules with bifunctional hdac therapeutics ejpmr, 2022,9(10), 107-116
  • enny AT, Rathinam P, Dev S, Mathew B, Radhakrishnan EK. Perillaldehyde mitigates virulence factors and biofilm formation of Pseudomonas aeruginosa clinical isolates, by acting on the quorum sensing mechanism in vitro. Journal of Applied Microbiology. 2022 Aug 1;133(2):385-99.
  • Mathew B, Scotti MT, Herrera-Acevedo C, Dev S, Rangarajan T, Kuruniyan MS, et al. Development of 2D, 3D-QSAR and Pharmacophore Modeling of Chalcones for the Inhibition of Monoamine Oxidase B. CCHTS. 2022 Aug;25(10):1731-44.
  • Nija B, Arun Rasheed, A Kottaimuthu. (2021) Development, characterization and pharmacological investigation of umbelliferone conjugates of NSAIDs, Iraqi journal of pharmaceutical sciences. (Accepted for publication)
  • Anusree v, jong minoh , sanal dev , elham amin , shebina p rasheed , ajeesh vengamthodi (2021) ,selected class of enamides bearing nitro functionality as dual acting with highly selective monoamine oxidase –B and BACE1 inhibitors, molecules, 26,6004
  • fahima rincy , Shebina p Rasheed , aiswaryapj, Aleena basher , Arshida tp, Basila p, Kadeeja tk, Raihan a abdu (2021) emergence of anti HIV phytoconstituents, Asian journal of pharmaceutical and health sciences ,volume 11, issue 3,
  • SanalDev, Natural Products Database Screening for the Discovery of Naturally Occurring SARS‐Cov‐2 Spike Glycoprotein Blockers,Chemistry Select 5 (42), 13309-13317.2020
  • SanalDev,(Hetero-)(arylidene) arylhydrazides as Multitarget-Directed Monoamine Oxidase Inhibitors, ACS Combinatorial Science,2020
  • SanalDev, Selected 1, 3‐benzodioxine‐containing chalcones as multipotent monoamine oxidase and acetylcholinesterase inhibitors.ChemMedChem, 2020
  • Fathima SahlaKavully, Jong Min Oh, Sanal Dev, SwafvanKaipakasseri, AshiquePalakkathondi, Ajeesh Vengamthodi, RinshanaFathima Abdul Azeez, Anna Rita Tondo, OrazioNicolotti, Hoon Kim,Bijo Mathew. Design of enamides as new selective monoamineoxidase-B inhibitors, Journal of Pharmacy and Pharmacology, 72(2020), https://doi.org/10.1111/jphp.13264.
  • Nija B, Arun Rasheed, Kottaimuthu A.(2020) Development, characterization and pharmacological evaluation of amino acid prodrugs of (+)-Ibuprofen. International journal of Research in Pharmaceutical sciences, 11(3) .4998-00
  • Nija B, Arun Rasheed, Kottaimuthu A. (2020) Synthesis, characterization and pharmacological investigation of lysine and glycine conjugated amide prodrugs of (+)-ibuprofen. International journal of Research in Pharmaceutical sciences. 11(3), 5022-30, 2020
  • Nija B, Arun Rasheed, A Kottaimuthu.(2020) Development, characterization and pharmacological investigation of sesamol and thymol conjugates of mefenamic acid, Journal of Evolution of Medical and Dental Sciences,9(52), 3909-3916.
  • Jasmine, S., Apina, K., Anusree, V., Pravathy, S L., Kais, MK., Balan, N., and Rasheed, A. (2020),Design, Synthesis and Pharmacological Evaluation of Flurbiprofen Prodrugs for Neurodegenerative Disorders. Asian Journal of Pharmaceutical and Health Sciences.,10(2),2262-2267
  • K A, Khais M, V A, VP T, SL P, B Nija, et al. New Facets of Neuroprotective Effects of Nonsteroidal Anti-inflammatory Drugs: A Comprehensive Review. Asian Journal of Pharmaceutical and Health Sciences. 2020;10(2):2231-2238.
  • Sumathi, A.; Suriyaprakash, T. N. K.; Balan, P. Immunomodulary therapy using phytosomes containing Nymphaea nouchali extract complexed with phospholipids. Current Trends in Biotechnology &Pharmacy . Apr2020 Suppl, p20-21. 2p.
  • Radhika C.*, Christy Benny, Rashida M., Balan P. and Prasanth S. S. Identification and Quantification of phytoconstituents in selected species of moringa. World Journal of Pharmacy and Pharmaceutical Sciences. 2020, Volume 9, Issue 5, 1841- 49. DOI: 10.20959/wjpps20205-16192.
  • Mythri M, SanalDev ,&Kottai Muthu A. (2020). Evaluation of the antioxidant activity of various extracts of aerial parts of Cassia absus: An in-vitro techniques. International Journal of Research in Pharmaceutical Sciences, 11(2), 1545-1550. https://doi.org/10.26452/ijrps.v11i2.2031.
  • Mythri M, SanalDev ,&Kottai Muthu A. (2020). Estimation of total phenolic content and evaluation of in vitro antioxidant activity of different extracts of Cassia absus (Linn) by Superoxide radical, Iron chelating activity. International Journal of Research in Pharmaceutical Sciences, 11(2), 1585-1589. https://doi.org/10.26452/ijrps.v11i2.2037
  • Anusree v, shebina p rasheed ,basil mohammed k.p , thasleena vp, parvathy s.l, mohammed khais(2020) identification and quantification of dndm hydantoin in selected shampoos der pharma chemical 12(6):31-35
  • Shebina p Rasheed , shivashankar m, (2020) synthesis comparative evaluation of traditional herbomineral nanoceutical for their haemopoetic activity, 11(4), 6463-6472
  • Shubham Srivastava, Ajeesh Vengamthodi, Inderpal Singh, Bhanwar Singh Choudhary, Manish Sharma and Ruchi Malik. Determination of comprehensive in-silico determinants as a strategy for identi cation of novel PI3K inhibitors, Structural Chemistry, 30, 1761–1778 (2019), doi:10.1007/s11224-019-01303-2
  • V. Ajeesh, S. Shubham and M. Ruchi. Design and Synthesis of Some Novel Erlotinib Derivatives As Potential EGFR Kinase Inhibitors, Royal Society of Chemistry special publication, 355, Conference on Drug Design and Discovery Technologies (2019),https://doi.org/10.1039/9781839160783-00095
  • SP Rasheed, M Shivashankar, S Dev, AK Azeem. Treatment of bio waste to pharmaceutical excipient ,Materials Today: Proceedings 15, 316-322.
  • SrinubabuMaddela, AjithaMakula, Mario D Galigniana, Della GT Parambi, Fernando Federicci, Gisela Mazaira, Omnia M Hendawy, Sanal Dev, Githa E Mathew, Bijo Mathew.Fe3O4 nanoparticles mediated synthesis of novel spirooxindole‐dihydropyrimidinone molecules as Hsp90 inhibitors,Arch Pharm. 2018;352:1800174.
  • Dev, Sanal; Thomas Parambi, Della G.; Baby, Bency; Mathew, Githa Elizabeth; Omnia Magdy, Hendawy; Joy, Monu; Sudev, Shine; Mathew, Bijo.An Environment-friendly Synthesis of Piperonal Chalcones and Their Cytotoxic and Antioxidant Evaluation.Letters in Drug Design & Discovery 17 (2), 138 – 144.
  • Della GT Parambi, FakhryaAljoufi, VikneswaranMurugaiyah, Githa E Mathew, Sanal Dev, BalasubramanainLakshminarayanan, Omnia M Hendawy, Bijo Mathew. Cholinesterase inhibitory activities of selected halogenated thiophene chalcones. Cent NervSyst Agents Med Chem. 2019; 19: 1-5.
  • Vadlamudi, H.C., Yalavarthi, P.R., Nagaswaram, T. Arun Rasheed, Peesa JP. J. Pharm. Investig. (2018). In-vitro and pharmacodynamic characterization of solidified self microemulsified system of quetiapine fumarate. Journal of Pharmaceutical Investigation.49 (1), 161-172, doi.org/10.1007/s40005-018-0397-1
  • Sanal Dev, Discovery of new class of methoxy carrying isoxazole derivatives as COX-II inhibitors: Investigation of a detailed molecular dynamics study, Journal of Molecular Structure,2018,1157,19-28.
  • SanalDev, Virtual Combinatorial Library Design, Synthesis and In vitro Anticancer Assessment of -2-Amino-3-Cyanopyridine Derivatives, Combinatorial Chemistry & High Throughput Screening, 2018, 21, 1-11
  • Balan P*, Ansiyasiraj, Balasubramanaian T and Suriyaprakash TNK. HPTLC Fingerprintings of Ethyl acetate Extract of Cynoglossum zeylanicum (Boraginaceae). European Journal of Biomedical and Pharmaceutical sciences. 2018, Volume 5, Issue 3, 901-906.
  • Balasubramanian Thirumalaisamy1, *, Lina Elizabeth Cherian2 , Balan Paramasivam3 , Jisna Jamal2 , MumthasArpurath Habeeb2 , Murshid Cheriyeri Peediyekal2. Management of Treatment Resistant Depression – A Systematic Review. American Journal of Psychology and Behavioral Sciences. 2018, Vol. 5, No. 3, 2018, pp. 67-71.
  • Neethu Varghese and Jemi Jacob. Evaluation of the Cytotoxicity Activity in the Leaves of NilgirianthusCiliatus (Linn) in Dalton’s Lymphoma Ascites cells. International Journal of Pharma and Bio Sciences. 2018;9(3): 208-212
  • Arun Rasheed,Yalavarthi PR, Cheramparambil H, Peesa JP, Abdul Khareem A. Synthesis and Pharmacological Evaluation of Acrylate-Based Gastrosparing NSAID Prodrugs.Archiv der Pharmazie, (Weinheim). 2017, 350(3-4). doi: 10.1002/ardp.201600325. Epub 2017
  • Vadlamudi HC, Yalavarthi PR, Arun Rasheed, In vitro characterization studies of self-microemulsifiedbosentan systems. Drug Dev Ind Pharm. 2017, 43(6):989-995.doi: 10.1080/03639045.2017.1287720. Epub 2017 Feb 16\
  • Peesa JP, Atmakuri LR, Yalavarthi PR, Mandava Venkata BR, Arun Rasheed A, Pachava. Oxaprozin prodrug as safer nonsteroidal anti-inflammatory drug: Synthesis and pharmacological evaluation. Arch Pharm Chem Life Sci. 2017; 18. doi.org/10.1002/ardp.201700256
  • SanalDev,Novel HDAC8 Inhibitors: A Multi-Computational Approach,SAR and QSAR in Environmental Research,2017, 28 (9), 707-733.
  • SanalDev, Synthetic Approaches to Various Class of Topoisomerase II Inhibitors, Mini-Reviews in Organic Chemistry 2017,14 (5), 357-374.
  • Pharmacophore Based 3D-QSAR Analysis of Thienyl Chalcones as a New Class of Human MAO-B Inhibitors. Investigation of Combined Quantum Chemical and Molecular Dynamics Approach, J. Phys. Chem. B, 2017, 121 (6), 1186–1203.
  • Shebina Rasheed, Sanal Dev, K Remya, Jemi Jacob, Smitha RaniDetermination of Esomeprazole by Complexation Method, Der Pharma Chemica, 2017, 9(22):101-105.
  • SanalDev, Refining the Structural Features of Chromones as Selective MAO‐B Inhibitors: Exploration of Combined Pharmacophore‐Based 3D‐QSAR and Quantum Chemical.. Chemistry Select,2017, 2 ,(35),11645-11652.
  • Neethu Varghese, Jemi Jacob, Mythri M, Nija B., Sheeba Jasmine T. S.“Synthesis of Thiazole Derivatives—A Review” World Journal of Pharmacy and Pharmaceutical Sciences.2016: 5(11), 624-636
  • Jemi Jacob, Neethu Varghese, Shebina P Rasheed, Supriya Agnihotri, Vidushi Sharma, Sharad Wakode. Recent Advances in the Synthesis of Isoquinoline and its analogue: A Review. World Journal of Pharmacy and Pharmaceutical Sciences. 2016: 5(7), 1821-1837
  • Sheebajasmin TS, NA Aleykutty, Jyoti Harindran, Aravind A, Neethu Varghese. “Optimization of microwave assisted extraction of Pseudarthriaviscidalinn leaves” International journal of Pharma Research. 2015, 6(2): 17-20
  • Jemi Jacob, Neethu Varghese, Shebina P Rasheed ,Vidushi Sharma, SupriyaAgnihotri “Recent Advances in the Synthesis of Isoquinoline and its Derivatives: A Review” ,World Journal of Pharmacy and Pharmaceutical sciences , Volume 5 issue 7, Page 1821-1827, 2016
  • Neethu Varghese, JemiJacob, Mythri M , Nija B., Sheeba Jasmine T.S.“Synthesis of Thiazole derivatives : A Review” ,World Journal of Pharmacy and Pharmaceutical sciences , Volume 5 issue 11, Page 624-636, 2016
  • Jaya Preethi Peesa, Prasanna Raju Y, Arun Rasheed, Venkata Basaveswara Rao Mandava, A perspective review on role of novel NSAID prodrugs in the management of acute inflammation, Journal of Acute Disease, 2016; 5(5): 364–381
  • Arun Rasheed, Prasanna Raju Y, Jamal Basha D, Anvesh M, Azeem AK, Process and Pharmacological Potentials of Kasisabhasma, a Herbo-Mineral Formulation with Calcinated Ferrous Sulphate, Jordan Journal of Pharmaceutical Sciences, 2016, 9 (2), 141-154.
  • Arun Rasheed, Lathika G, Raj Y.P., Synthesis and pharmacological evaluation of mutual prodrugs of aceclofenac with quercetin, vanillin and l-tryptophan as gastrosparing NSAIDS, Medicinal Chemistry Research (2016), 25: 70. doi:10.1007/s00044-015-1469-7
  • JP Peesa, PR Yalavarthi, Arun Rasheed, VBR MandavaA perspective review on role of novel NSAID prodrugs in the management of acute inflammation, 2016, Journal of Acute Disease5 (5), 364-381.
  • SanalDev,“Discovery of Camptothecin based Topoisomerase I Inhibitors: Identification Using an Atom based 3D-QSAR, Pharmacophore Modeling, Virtual Screening and Molecular Docking Approach”,Combinatorial Chemistry & High Throughput Screening, 2016, 19 (9), 752-763.
  • SanalDev, Pharmacophore Modeling, 3D-QSAR and Molecular Docking of Furanochalcones as Inhibitors of Monoamine Oxidase-B. Central nervous system agents in medicinal chemistry. 2016,16,(2), 105-111.
  • SanalDev, Molecular Docking Studies of Some Novel Antidepressant 5-Substituted Phenyl-3-(Thiophen-2-yl)-4, 5-Dihydro-1h-Pyrazole-1-Carboxamides against Monoamine Oxidase Isoforms. Central nervous system agents in medicinal chemistry, 2016,16,(2),75-80.
  • JP Peesa, PR Yalavarthi, Arun Rasheed, VBR MandavaA perspective review on role of novel NSAID prodrugs in the management of acute inflammation, 2016, Journal of Acute Disease 5 (5), 364-381.
  • Balasubramanian T, Balan P, Suriyaprakash TNK. Effect of potent ethyl acetate extract of Amaranthus hybridus instreptozotocin-induced diabetic rats. Int. J. of Res. in Pharmacology & Pharmacotherapeutics. 2016; Special Issue-1; 120-9.
  • Balan P, Sumathi A, Suriyaprakash TNK. HPTLC method for the quantification of ellagic acid in different Eucalyptus species. World Journal of Pharmaceutical Sciences. 2016; 4(10): 210-2.
  • KR Vandana, Prasanna Raju Yalavarthi, Harini Chowdary Vadlamudi, Jagadesh Kumar Yadav Kalluri, Arun Rasheed, Process, Physicochemical Characterization and In-Vitro Assessment of Albendazole Microcrystals, Adv Pharm Bull, 2016,7 (3), 419 doi: 10.15171/apb.2016.000
  • R.Nanda Kishore, Prasanna Raju Yalavarthi, Harini Chowdary Vadlamudi, K.R. Vandana, Arun Rasheed, M. Sushma, Solid self microemulsification of Atorvastatin using hydrophilic carriers: a design, Drug Development and Industrial Pharmacy, 2015, 41(7):1213-22. Doi: 10.3109/03639045.2014.938655
  • Asuntha G, Raju Y Prasanna, Sundaresan CR, Arun Rasheed, Chowdary V Harini, Vandana KR, Babu K Satish, Prasad KVSRG, Effect of Argemone mexicana (L.) against lithium-pilocarpine induced status epilepticus and oxidative stress in wistar rats, 2015, Indian Journal of Experimental Biology, 53 (01), pp. 31-35,
  • Nanda Kishore, Prasanna Raju Y, Harini Chowdary V, K. R. Vandana, Arun Rasheed and M. Sushma, Solid self microemulsification of Atorvastatin using hydrophilic carriers: a design, Drug Development and Industrial Pharmacy, 2015; 41(7): 1213–1222
  • ArunRasheed,Anvesh Marri and M. Madhu Naik, Formulation, characterization and comparative evaluation of Trivangabhasma: A herbo-mineral Indian traditional medicine. Pakistan Journal of pharmaceutical sciences, 27, 4, 2014, pp.793-800
  • ArunRasheed, S. NeelufarShama, and M.Teja Sri, Formulation, standardization and pharmacological studies of Saraswataristam: A polyherbal preparation, Pakistan Journal of pharmaceutical sciences, 27,3,2014, pp.551-557
  • Asuntha G, Prasanna Raju Y, Harini Chowdary V, Vandana KR, Arun Rasheed, Prasad KVSRG, Pharmacological profiling of Argemone mexicanafor its aphrodisiac potentials in male Wistar rats,Asian Pacific Journal of Reproduction, 2014; 3(2): 110-115
  • Arun Rasheed, Sravya Reddy B., Roja C., Azeem AK, Formulation and Evaluation of Poly Herbal Formulation against CCl4 Induced Hepatotoxicity, Jordan Journal of Pharmaceutical Sciences, 7(1), 2014, 67-76
  • SanalDev, Proposed interaction of some novel antidepressant pyrazolines against monoamine oxidase isoforms. Molecular docking studies and PASS assisted in silico approach. Biomedicine & Aging Pathology, 2014, 4 (4), 297-301.
  • Balan P, Kannappan N. Development and Validation of Stability-Indicating RP-UPLC Method for Simultaneous Estimation of Etodolac and Paracetamol in Combined Dosage Form. Journal of Scientific Research in Pharmacy. 2014; 3(1): 33-7.
  • Balan P, Kannappan N. Development and Validation of Stability-Indicating RP-UPLC Method for Simultaneous Estimation of Thiocolchicoside and Aceclofenac in Combined Dosage form. International Current Pharmaceutical Journal. 2014; 3(7): 296-300.
  • Balan P, Kannappan N. Development and Validation of Stability-Indicating RP-UPLC method for Simultaneous Estimation of Thiocolchicoside and Ketoprofen in Combined Dosage form. World Journal of Pharmaceutical Research. 2014; 3(4): 1129-41.
  • Balan P, Kannappan N, Narasimha CRB. Simultaneous Estimation of Olopatadine hydrochloride and ketorolac tromethamine in bulk and Pharmaceutical dosage form by RP-HPLC method. International Journal of Research and Pharmaceutocal Science. 2014; 5(1): 14-9.
  • Levin Thomas, Jayakrishnan SS, Sheron Joseph, Neethu Varghese, Dilip C, Arun Rasheed. Assessment of OTC drug labels for patient information in community pharmacies in Thiruvananthapuram city”. International Journal of Innovative Pharmaceutical Sciences and Research. 2014, 2(5): 1034-104
  • Sheron Joseph, Neethu Varghese, Levin Thomas. “A study on prescribing pattern of anti-hypertensive medications in a tertiary care hospital in Malabar region”. Der Pharmacia Lettre, 2014, 6 (4):132-137
  • Neethu Varghese, Sheron Joseph, Sheeba Jasmine TS, Divya GS. “Study of phytochemical and antimicrobial potential of the leaves of Nilgirianthusciliatuslinn”. International Journal of Applied Biology and Pharmaceutical Technology. 2014, 5(3):150-152
  • Arun Rasheed, S. Yeswanth, T. Lokesh, K. Prasad, T. Uday Kumar and M. Krishna Teja, DevelopmentandvalidationofUVspectroscopicmethodfordeterminationofaprepitantinbulkandcapsuleformulation, Inventi Rapid: Pharm: Analysis & Quality Assurance, 2013(2): 1-4, 2013.
  • Arun Rasheed, Krishna Teja, Mounika P, Azeem A K, Prashanth S S. Development andValidation of Rifaximin in Tablet Formulation by VariousUV-Spectroscopical Methods. Inventi Rapid: Pharm Analysis & Quality Assurance, 2013(2): 1-4, 2013.
  • Arun Rasheed, Mounika P, Azeem AK, Prashanth S S. Development and Validation of Silodosin in Tablet Formulation by Various UVSpectrophotometric Methods. Inventi Rapid: PharmAnalysis & Quality Assurance, 2013(2): 1-5, 2013.
  • ArunRasheed, Sathyanaryana KV, Sindhura Rao and Swetha Gulabi, Chemical and Pharmacological evaluation of ayurvedic formulations of aswagandhadilehyam: A modern approach to standardization,Journal of Complementary and Integrative Medicine,Germany, 2013; 10(1): 1–9
  • SanalDev ,A solvent-free protocol for the green synthesis of heterocyclic chalcones, Der Pharmacia Lettre, 2013, 5 (5):219-223.
  • SanalDev, Identification of Potent Virtual Leads as Topoisomerase-II Inhibitors Using Pharmacophore Modelling, Molecular Docking and ADME Studies.2013,IJPSR, 4(8):2939-2934
  • Prabu SL, Thiyagarajan S, Balan P, Suriyaprakash TNK, Sharavanan SP. Development and Validation of Stability indicating RPHPLC Method for Coumarin Assay in Bulk Drugs and Pharmaceutical Products. International Journal of Pharmaceutical Sciences and Nanotechnology. 2013; 6(3): 2187-92
  • ArunRasheed, C. Roja, Sravyareddy, Avinashkumar,Formulation, standardization and pharmacological evaluation of a poly herbal traditional remedy - Ashwagandharishtam, Oriental Pharmacy and Experimental Medicine (OPEM),2012, 12:51- 58, Springer
  • Arun Rasheed, NeelufarShama, S. Mohana Lakshmi and Ravichandran.V, Formulation and In Vitro Evaluation of Herbal Sunscreen LotionFormulation, Characterization and in vitro evaluation of herbal sunscreen lotion, Oriental Pharmacy and Experimental Medicine (OPEM), December 2012,12 (4): 241-246.
  • Nimila IC, Balan P, Chiranjeevi N, Kumar VVM. Development and validation of a Reverse Phase HPLC method of simultaneous estimation of Tolperisone hydrochloride and Paracetamol in tablet dosage form. International Journal of Pharmacy and Pharmaceutical Sciences. 2012; 4 (5): 84-8.
  • Ravichandran Veerachamy, Ooi Chia Chean, Dinesh Kumar subramaniam, Ng mei Ying, Shalini Sivadasan and Arun Rasheed, Designing hypothesis of diaryl pyrimidine analogs as anti-HIV agent: QSAR approach, Medicinal Chemistry Research, 2013, 22, 1, pp 35-44.
  • Arun Rasheed, Ashok Kumar C.K. and Ashutosh Mishra, Synthesis, Hydrolysis Studies and Phamacodynamic Profiles of Amide Prodrugs of Dexibuprofen with Amino Acids, Journal Of Enzyme Inhibition and Medicinal Chemistry, 26, (5) 688-695 ,(2011),
  • Arun Rasheed, Sagar P., Saipriya K., Priyanka B. and Saravana Kumar A., Design of polymeric prodrugs of ibuprofen using dextran: synthesis, hydrolytic behaviour, pharmacological and antigenicity studies, Lat. Am. J. Pharm (formerly Acta FarmacéuticaBonaerense). 30 (3): 473-9 (2011).
  • Arun Rasheed, Krishna U, Sivakrishna Reddy P, Ashuthosh Mishra A., Synthesis and characterization of novel dextran-conjugated macromolecules of aceclofenac,Ars Pharmaceutica, 2011; 52(1): 5-11.
  • Arun Rasheed and Ashok Kumar C.K., Synthesis and Pharmacological Evaluation of Tyrosine and Glycine Conjugates of Aceclofenac, Jordan Journal of Pharmaceutical Sciences, 4(3):198-208 (2011),University of Jordan, Amman, Jordan
  • Arun Rasheed, K V Satyanarayana, P Swetha Gulabi, M. Sindhura, S. NeelufarShama and Avinash Kumar Reddy, Standardization: accessing key for herbal drug safety assurance, Journal of Pharmaceutical Research, 4(5), 1322-1325, (2011). Impact Factor: 1.09
  • Avinash Kumar Reddy G., Jyothi M. Joy, Arun Rasheed, Ashok Kumar, C K, Pharmacognostical and phytochemical study on leaves of Lanneacoromandelica(houtt) Merr. Int. J.Pharm. Pract& Drug res,1(1), 2011, 14-20.
  • ArunRasheed, Anvesh Marri, and M. Madhu Naik, Standardization of bhasma-importance and prospects, Journal of Pharmaceutical Research, 4(6), 1931-1933, (2011).
  • Balan P,Nimila IC, Prasana ML, Vanajarani M, Rajasekar S. Simultaneous estimation of Etodolac and Paracetamol by UV Spectrophotometric Method in Tablet Formulation. Journal of Pharmacy Research. 2011; 4(6): 1663-5.
  • Balan P,Nimila IC, Vanajarani M, Prasana ML, Rajasekar S. Simultaneous Estimation of Dexibuprofen and Paracetamol by UV Spectrophotometric Method in Bulk and Tablet Formulation. Inventi Rapid: Pharm Ana & Qual. Assur. 2011; 2(1).
  • Balan P, Nimila IC, Radhika K, Prasana ML, Vanajarani M, Rajasekar S. Method Development and Validation of Etodolac in Tablet Dosage Form by UV Spectroscopy. Inventi Rapid: Pharm Ana & Qual. Assur. 2011, 2(2).
  • Nimila IC, Balan P, Chiranjeevi N, Umamheswari V, Rajasekar S. Method Development and Statistical Validation of UV Spectrophotometric Method for TolperisoneHydrochloiride in Bulk and Tablet Dosage Form. Journal of Pharmacy Research. 2011; 4(5): 1356-7.
  • Nimila IC, Balan P, Chiranjeevi N, Umamaheswari V, Karthikeyan M. Method Development, Validation and forced degradation studies of Tolperisone Hydrochloride by RP-HPLC Method in Bulk and Tablet Dosage Form. International Journal of Pharma and Bio Sciences. 2011; 2(4): 587-95.
  • NimilaIC, Balan P, Sundar RS, Ashokkumar J, Rajasekar S. Simultaneous RP-HPLC Estimation of Ciprofloxacin Hydrochloride and Ornidazole in Tablet Dosage Form. Asian J. Research Chem. 2011; 4(2): 227-30.
  • Balan P,Nimila IC, Prasana ML, Vanajarani M, Rajasekar S. RP-HPLC Method Development and Validation of Etodolac and Paracetamol in Combined Dosage Form. Asian J. Research Chem. 2011; 4(7): 1073-6.
  • Balan P,Nimila IC, Vanajarani M, Prasana ML, Rajasekar S. A Validated RP-HPLC Method for Estimation of Dexibuprofen and Paracetamol in Combined Tablet Dosage Form. International Journal of Pharm.Tech. Research. 2011; 3(3): 1293-8.
  • Balan P, Nimila IC, Sasirekha C, Vanajarani M, Rajasekar S. A Validated RP-HPLC Method For Estimation Of Drotaverine HCL In Pharmaceutical Tablet Dosage Form. Int. J .Pharm. Pharm Sci. 2011; 3(4): 77-80.
  • Arun Rasheed and Ashok Kumar C.K., Design, Synthesis, Hydrolysis Kinetics and Pharmacodynamic Profiles of Histidine and Alanine Conjugates of Aceclofenac, Acta Pharmaceutica,2010,60: 99–109.
  • Arun Rasheed and Ashok Kumar C.K., Tyrosine and Glycine Derivatives as Potential Prodrugs: Design, Synthesis and Pharmacological Evaluation of Amide Derivatives of Mefenamic Acid, Journal of Enzyme Inhibition and Medicinal Chemistry, 2010, 25 (6), 804-811
  • Nimila IC, Balan P, Kumar KY, Rajasekar S. Simultaneous Estimation of Diacerein and Aceclofenac in Bulk and Pharmaceutical Dosage form by UV Spectroscopy Method. International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN: 0974-4304. 2010; 2: 2313-8.
  • Chavan RA, Patil MA, Salunke TB, Balan P.Development and Evaluation of Orodispersible tablets of Lisinopril: An Ace Inhibitor.Inventi Rapid: Pharm Tech. 2010; 1(1).
  • NV Prasanth, C Dilip, KT Sanal Dev, L Augustine, R Saraswathi,Evaluation of in vitro cytotoxic and antioxidant activities of Ipomoea batatas. Int J Pharm Pharm Sci 2010;2:91-2.
  • Jemi Jacob, Parthiban P*, AlagarsamyV ,Hanish Singh JC Sathesh Kumar S ,Subhash Chandra Bose, “Synthesis, Characterization and Antimicrobial screening of 3-(5- substituted phenyl- 1, 3, 4 – oxadiazol- 2 – yl) pyridines”, International Journal Of Pharmaceutical Sciences And Research, Volume 1, Issue 8, Page 109-114, 2010
  • Arun Rasheed, Ashok Kumar C.K., Ravichandran V. and Purushothaman M., Prodrug Design of NSAIDs: Synthesis and Pharmacological Profiles of Amide Prodrugs of Etodolac with Amino Acids, Lat. Am. J. Pharm (formerly Acta FarmacéuticaBonaerense). 30 (1): 73-80 (2011).
  • Arun Rasheed, Theja I., Ashok Kumar C.K, Lavanya Y., Ravindra Royal P. and Vamsee Krishna S., Synthesis, Hydrolysis Studies and Pharmacodynamic Profiles of Novel Colon-Specific Mutual Prodrug of Aceclofenac with Amino Acids, Der Pharma Chemica, 2009, 1 (2): 59-71.
  • Arun Rasheed, Ashok Kumar C.K., Synthesis, Hydrolysis and Pharmacodynamic Profiles of Novel Prodrugs of Mefenamic Acid, International Journal of Current Pharmaceutical Research, 2009, 1 (1): 47-55.
  • Arun Rasheed, Sathish Y., Sravanthi V.V.N.S.S., Vamsi Krishna K. and Theja I., Design, Hydrolysis and Pharmacological Evaluation of Novel Polymeric Prodrugs of Etodolac, Der Pharmacia Lettre, 2009, 1 (2): 9-17.
  • Arun Rasheed, Aishwarya K., Niyaz Basha B., Sravya Reddy B. and Swetha A., Dexibuprofen-Dextran Macromolecular Prodrugs: Synthesis, Characterization and Pharmacological Evaluation, Der Pharma Chemica, 2009, 1 (2): 124-132.
  • SanalDev, Synthesis and pharmacological evaluation of Gastro sparing mutual prodrug of Aceclofenac with Glucosamine. In Pharm Communique,2009 2(3): 17 - 22.
  • Arun Rasheed, Theja I., Silparani G., Lavanya Y. and Ashok Kumar C.K., CNS Targeted Drug Delivery: Current Perspectives, Journal of Innovative Trends in Pharmaceutical Sciences, 2010, 1 (1), 8-17.
  • Arun Rasheed, Ashok Kumar C.K. and Sravanthi V.V.N.S.S., Cyclodextrin as a Drug Carrier Molecule: A Review, Scientia Pharmaceutica, 2008, 76: 567-598.
  • Arun Rasheed and Ashok Kumar C.K., Novel Approaches on Prodrug based Drug Design, Pharmaceutical Chemistry Journal, 2008, 42 (12): 677-686. Springer.
  • Dhaneshwar S, Dev S, Mhaske D, Kadam S. Synthesis and pharmacological evaluation of cyclodextrin conjugate prodrug of mefenamic acid. Indian J Pharm Sci. 2007;69(1):69.
  • SanalDev, Synthesis and pharmacological screening of cyclodextrin conjugates of Ibuprofen, Indian Journal of Pharmaceutical Sciences. 2005, 67(4):432-43
  • Sankar V, Raghuraman S, Sulthana MT, Ravichandran V. Ampicillin prodrugs: amide conjugates from amino acids and ampicillin. Pharmazie. 2001 Jul;56(7):588-9.
  • Rasheed A, Ravichandran V, Kohli DV. Ampicillin prodrugs: amide conjugates from aminoacids, peptide and ampicillin. Pharmazie. 1999 Nov;54(11):857-8.
Campus Tour
E Brochure

Search Something